KIRREL2 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS60707
Background:
NEPH3 (nephrin-like protein 3), also referred to as NLG1, FILTRIN or KIRREL2 (kin of IRRE like 2), is a 708 amino acid protein that is a member of the immunoglobulin superfamily of cell adhesion molecules. NEPH3 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues. NEPH3 localizes to the interpodocyte filtration slit in the kidney and to the Langerhans islet beta cells in the pancreas. NEPH3 is thought to be involved in the maintenance of the glomerular filtration barrier in the kidney and in pancreas development. Downregulation of NEPH3 is implicated in several proteinuric diseases. Five isoforms exists due to alternative splicing events.
Alternative Name:
Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, Nephrin-like protein 3, KIRREL2NEPH3, UNQ5827, PRO19646
Application Dilution: WB: 1:500~1:1000
Specificity: KIRREL2 polyclonal antibody detects endogenous levels of KIRREL2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human KIRREL2
MW: ~ 75 kDa
Swis Prot.: Q6UWL6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
NEPH3 (nephrin-like protein 3), also referred to as NLG1, FILTRIN or KIRREL2 (kin of IRRE like 2), is a 708 amino acid protein that is a member of the immunoglobulin superfamily of cell adhesion molecules. NEPH3 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues. NEPH3 localizes to the interpodocyte filtration slit in the kidney and to the Langerhans islet beta cells in the pancreas. NEPH3 is thought to be involved in the maintenance of the glomerular filtration barrier in the kidney and in pancreas development. Downregulation of NEPH3 is implicated in several proteinuric diseases. Five isoforms exists due to alternative splicing events.
Alternative Name:
Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, Nephrin-like protein 3, KIRREL2NEPH3, UNQ5827, PRO19646
Application Dilution: WB: 1:500~1:1000
Specificity: KIRREL2 polyclonal antibody detects endogenous levels of KIRREL2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human KIRREL2
MW: ~ 75 kDa
Swis Prot.: Q6UWL6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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