KLC1 Polyclonal Antibody

Background:
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
Kinesin 2 60/70kDa, Kinesin light chain 1, Kinesin2, KLC 1, KLC, Klc1, KLC1, KNS 2, KNS 2A, KNS2, KNS2A, Medulloblastoma antigen MU MB 2.50, MGC15245

Immunogen: Recombinant protein of human KLC1

Swissprot: Q07866
Gene Accession: BC008881

Calculated MW: 65 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-13361/sc-13362/sc-25735