KLF1 polyclonal (C-Term), anti-human
€0.00
In stock
SKU
AC-AP22456b
Catalog Number: AC-AP22456b
Size: 50 µl, 200 µl
Isotype: Rabbit Ig
Clone Name: R02929
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit Ig
Clone Name: R02929
Applications: WB
Datasheet
Request Information
Background:
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Other Names:
Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Target/Specificity:
This KLF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human KLF1.
Antigen Type: Recombinant Protein
Gene Name: KLF1
Gene ID: 10661
Primary Accession: Q13351
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Other Names:
Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Target/Specificity:
This KLF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human KLF1.
Antigen Type: Recombinant Protein
Gene Name: KLF1
Gene ID: 10661
Primary Accession: Q13351
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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