KLF4 Polyclonal Antibody

Background:
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms:
EZF, GKLF, KLF4

Immunogen: Recombinant fusion protein of human KLF4 (NP_004226.3).

Swissprot: O43474
Gene ID: 9314

Calculated MW: 6 kDa/12 kDa/45 kDa/51 kDa/54 kDa
Observed MW: 50 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.