KLF7 rabbit polyclonal, anti-human, mouse

Backgroud: The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],domain:The acidic N-terminal part may favor interaction with the basic domain of transcription factors.,function:Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.,

Synonyms: KLF7, UKLF, Krueppel-like factor 7, Ubiquitous krueppel-like factor

Gene Name: KLF7

Gene ID: 8609

SwissProt ID: O75840

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.