KLKB1 polyclonal (C-term), anti-human
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In stock
SKU
AC-AP14109b
Catalog Number: AC-AP14109b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34055
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34055
Applications: WB
Datasheet
Request Information
Background:
Plasma prekallikrein is a glycoprotein that participatesin the surface-dependent activation of blood coagulation,fibrinolysis, kinin generation and inflammation. It is synthesizedin the liver and secreted into the blood as a single polypeptidechain. Plasma prekallikrein is converted to plasma kallikrein byfactor XIIa by the cleavage of an internal Arg-Ile bond. Plasmakallikrein therefore is composed of a heavy chain and a light chainheld together by a disulphide bond. The heavy chain originatesfrom the amino-terminal end of the zymogen and contains 4 tandemrepeats of 90 or 91 amino acids. Each repeat harbors a novelstructure called the apple domain. The heavy chain is required forthe surface-dependent pro-coagulant activity of plasma kallikrein.The light chain contains the active site or catalytic domain of theenzyme and is homologous to the trypsin family of serine proteases.Plasma prekallikrein deficiency causes a prolonged activatedpartial thromboplastin time in patients.
Other Names:
Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain, KLKB1, KLK3
Target/Specificity:
This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human KLKB1.
Antigen Region:
508-537
Antigen Type: Synthetic Peptide
Gene Name: KLKB1
Gene ID: 3818
Primary Accession: P03952
NCBI Accession: NP_000883.2
Other Accession: NP_000883.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Plasma prekallikrein is a glycoprotein that participatesin the surface-dependent activation of blood coagulation,fibrinolysis, kinin generation and inflammation. It is synthesizedin the liver and secreted into the blood as a single polypeptidechain. Plasma prekallikrein is converted to plasma kallikrein byfactor XIIa by the cleavage of an internal Arg-Ile bond. Plasmakallikrein therefore is composed of a heavy chain and a light chainheld together by a disulphide bond. The heavy chain originatesfrom the amino-terminal end of the zymogen and contains 4 tandemrepeats of 90 or 91 amino acids. Each repeat harbors a novelstructure called the apple domain. The heavy chain is required forthe surface-dependent pro-coagulant activity of plasma kallikrein.The light chain contains the active site or catalytic domain of theenzyme and is homologous to the trypsin family of serine proteases.Plasma prekallikrein deficiency causes a prolonged activatedpartial thromboplastin time in patients.
Other Names:
Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain, KLKB1, KLK3
Target/Specificity:
This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human KLKB1.
Antigen Region:
508-537
Antigen Type: Synthetic Peptide
Gene Name: KLKB1
Gene ID: 3818
Primary Accession: P03952
NCBI Accession: NP_000883.2
Other Accession: NP_000883.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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