KMT2A (clone 4A5A12), anti-human
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In stock
SKU
BT-MCA2037
Catalog Number: BT-MCA2037
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s):
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s):
Datasheet
Request Information
Background:
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Research Area: Others
Synonyms: HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS
Immunogen: Purified recombinant fragment of human KMT2A (AA: 801-956) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Research Area: Others
Synonyms: HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS
Immunogen: Purified recombinant fragment of human KMT2A (AA: 801-956) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
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