(KO Validated) POR Polyclonal Antibody

Background:
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
POR, CPR, CYPOR, P450R

Immunogen: Recombinant fusion protein of human POR (NP_000932.3).

Swissprot: P16435
Gene ID: 5447

Calculated MW: 76 kDa
Observed MW: 77 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.