KPI-2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009],catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates PPP1C, phosphorylase b and CFTR.,online information:LMTK2 entry,PTM:Autophosphorylated. Phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1C and inhibitor-2.,tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas.,

Synonyms: LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2, Serine/threonine-protein kinase LMTK2, Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, hBREK, CDK5/p35-regulated kinase, CPRK, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2

Gene Name: LMTK2

Gene ID: 22853

SwissProt ID: Q8IWU2

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.