KPNA2 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254357
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind “cargo” and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.
Alternate Names: KPNA2, Karyopherin alpha nucleoprotein interactor 2, Importin alpha2, IPOA1, RAG cohort protein 1, RCH1, SRP1, QIP2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_002257
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KPNA2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind “cargo” and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.
Alternate Names: KPNA2, Karyopherin alpha nucleoprotein interactor 2, Importin alpha2, IPOA1, RAG cohort protein 1, RCH1, SRP1, QIP2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_002257
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KPNA2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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