KPNA3 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254358
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.
Alternate Names: KPNA3, Karyopherin alpha nucleoprotein interactor 3, importin alpha 4, IPOA4, importin-alpha-Q2, QIP2, SRP4
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_002258
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KPNA3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.
Alternate Names: KPNA3, Karyopherin alpha nucleoprotein interactor 3, importin alpha 4, IPOA4, importin-alpha-Q2, QIP2, SRP4
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_002258
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KPNA3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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