KPNA6 polyclonal, anti-human

Background:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

Other Names:
Importin subunit alpha-7, Karyopherin subunit alpha-6, KPNA6, IPOA7

Antigen Types:
Synthetic Peptide

Gene Name:
KPNA6
Gene ID:
23633
Primary Accession: O60684
Other Accession: NP_036448;23633;16650 (mouse); 362607 (rat);