KRIT1 antibody (clone 2C7), anti-human
€435.00
In stock
SKU
AC-AT2652a
Catalog Number: AC-AT2652a
Size: 100 µg
Isotype: mouse IgG2a lambda
Applications: E
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Size: 100 µg
Isotype: mouse IgG2a lambda
Applications: E
Request Information AC-AT2652a">Request Information
Background:
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
Other Names:
Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1, CCM1
Antigen Type:
Recombinant Protein
Gene Name: KRIT1
Gene ID: 889
NCBI Accession: NP_001013424.1;NP_004903.2;NP_919436.1;NP_919437.1;NP_919438.1
Primary Accession: O00522
Other Accession: NM_004912
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
Other Names:
Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1, CCM1
Antigen Type:
Recombinant Protein
Gene Name: KRIT1
Gene ID: 889
NCBI Accession: NP_001013424.1;NP_004903.2;NP_919436.1;NP_919437.1;NP_919438.1
Primary Accession: O00522
Other Accession: NM_004912
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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