KSHV ORF45 (clone 2D4A5), anti-virus
€539.00
In stock
SKU
252608
Protein Family: Cellular Antigens
Pathway and Disease: Immune System, Infectious Diseases
Description:
KSHV (Kaposi's sarcoma-associated herpesvirus) belongs to the gamma-2 herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. It was reported that the ORF45 protein was associated with purified virions.
Alternate Names: ORF45
Application Notes: WB: 1:500-1:2000, ICC: 1:200-1:1000
Accession No.: F5HDE4
Antigen: Purified recombinant fragment of KSHV ORF45 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System, Infectious Diseases
Description:
KSHV (Kaposi's sarcoma-associated herpesvirus) belongs to the gamma-2 herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. It was reported that the ORF45 protein was associated with purified virions.
Alternate Names: ORF45
Application Notes: WB: 1:500-1:2000, ICC: 1:200-1:1000
Accession No.: F5HDE4
Antigen: Purified recombinant fragment of KSHV ORF45 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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