Ku (86 kd subunit) (clone J15), anti-human, monkey

Source:
A BALB/c mouse was immunized with A431 cells (human epidermoid carcinoma).
Fusion partner: X63-Ag8.653.

Specifications:
J15 recognizes an epitope within aa 490 to 707 of the 86 kDa subunit of Ku protein, involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. It serves as autoantigen in patients with rheumatic diseases.

Species reactivity:
Positive: human, monkey.

Applications:
J15 can be applied to immunohistology, IFA and Western blot.`
Frozen sections: +
Immunofluorescence: +
Paraffin sections: +
Western blot: +

Positive control: A431, HeLa cells.

References:
- This antibody has not been published.