KU70 Polyclonal Antibody

Background:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
XRCC6, CTC75, CTCBF, G22P1, KU70, ML8, TLAA

Immunogen: A synthetic peptide of human KU70 (NP_001460.1).

Swissprot: P12956
Gene ID: 2547

Calculated MW: 65 kDa/69 kDa
Observed MW: 70 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.