LAL (clone 9G7F12,7G6D7), anti-human
€421.00
In stock
SKU
252646
Protein Family: Enzymes
Pathway and Disease: Lipid Metabolism
Description:
LAL (Lysosomal acid lipase) is a 378-amino acid (~43-54 kDa) protein. It is found in the lysosomes to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. It is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, also in the intestine as well as in the lymph nodes, lungs, testes and ovaries.
Alternate Names: Lysosomal acid lipase/cholesteryl ester hydrolase, Acid cholesteryl ester hydrolase, LAL, Cholesteryl esterase, Lipase A, Sterol esterase
Application Notes: WB: 1:500-1:2000
Accession No.: P38571
Antigen: Purified recombinant fragment of LAL expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Lipid Metabolism
Description:
LAL (Lysosomal acid lipase) is a 378-amino acid (~43-54 kDa) protein. It is found in the lysosomes to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. It is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, also in the intestine as well as in the lymph nodes, lungs, testes and ovaries.
Alternate Names: Lysosomal acid lipase/cholesteryl ester hydrolase, Acid cholesteryl ester hydrolase, LAL, Cholesteryl esterase, Lipase A, Sterol esterase
Application Notes: WB: 1:500-1:2000
Accession No.: P38571
Antigen: Purified recombinant fragment of LAL expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review