Lambda Light Chain (B-Cell Marker) (clone N10/2), anti-human

Background:
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Other Names:
Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein

Gene Name: IGLV1-51 {ECO:0000303|PubMed:11872955, ECO:0000303|Ref.7}
Primary Accession: P01701
Other Accession: 449585; 3546,P01842