Lamin A/C (phospho-S22) polyclonal, anti-human, rat
€428.00
In stock
SKU
BS74023
Background:
Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Alternative Name:
Prelamin-A/C, Lamin-A/C, Lamin A/C, LaminA/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1, Lamin A, LaminA, Lamin-A, Lamin C, LaminC, Lamin-C
Application Dilution: WB: 1:500 - 1:2000, IP 1:50 - 1:100
Specificity: Lamin A/C (phospho-S22) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser22.
Immunogen:
A phospho specific peptide corresponding to residues surrounding S22 of human LMNA
MW: Predicted band size: 74, 65 kDa, Observed band size: 74, 65 kDa
Swis Prot.: P02545
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Alternative Name:
Prelamin-A/C, Lamin-A/C, Lamin A/C, LaminA/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1, Lamin A, LaminA, Lamin-A, Lamin C, LaminC, Lamin-C
Application Dilution: WB: 1:500 - 1:2000, IP 1:50 - 1:100
Specificity: Lamin A/C (phospho-S22) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser22.
Immunogen:
A phospho specific peptide corresponding to residues surrounding S22 of human LMNA
MW: Predicted band size: 74, 65 kDa, Observed band size: 74, 65 kDa
Swis Prot.: P02545
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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