Lamin B1 (clone 5G8-D3-H7), anti-human, mouse, monkey

Background:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

Synonyms: ADLD, LMN, LMN2, LMNB

Cellular Location: Lipid-anchor Nucleoplasmic side Nucleus inner membrane

Immunogen:
Recombinant human Lamin B1 protein.

Gene Symbol: Lamin B1

Gene ID: 4001

Swiss prot: P20700

Calculated MW: 68kDa

Recommended dilution:
WB 1:500

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.