Lamin-B1 polyclonal, anti-human, mouse, rat

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signaling Molecules and Interaction

Description:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and interact with chromatin. Defects in lamin-B1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD). ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life.

Alternate Names: Lamin-B1, LMNB1, LMN2, LMNB

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P20700

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human lamin-B1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.