LAMP-1(Center) polyclonal, anti-human, mouse, rat antibody

Background:
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is tho µght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, s µggesting that each protein possesses some unique and necessary functions.

Other Names:
LAMP-1, Lysosome associated membrane protein 1

Primary Accession: P11279

Gene Name: LAMP1

Gene ID: 3916

Concentration (mg/ml): 1 mg/ml