LAMP-2 polyclonal, anti-human, mouse

Protein Family: Cellular Antigens, Chaperones and Folding Catalysts

Pathway and Disease: Cancers, Folding, Sorting and Degradation, Infectious Diseases, Membrane Transport

Description:
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon’s disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

Alternate Names: LAMP-2, Lysosome associated membrane protein 2, Lysosome associated membrane glycoprotein 2, Lamp2, CD107b, CD107 antigen-like family member B

Application Notes: E: 1:1,000-1:2,000; WB: 1:500-1:1,000; ICC: 1:100-1:500

Accession No.: NP_054701

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term end of human LAMP-2.

Format: Each vial contains 0.1 mg (1 mg/ml) IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.