LAMP1 polyclonal, anti-human

Background:
Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Alternative Name:
LAMP-1, Lysosome-associated membrane protein 1, LAMP1, CD107 antigen like family member A, CD107 antigen-like family member A, CD107a, CD107a antigen, LAMP 1, LAMP-1, LAMP1, LAMP1, LAMPA, LGP120, lgpA, Lysosomal membrane glycoprotein 120KD, Lysosomal Associated Membrane Protein 1, Lysosome associated membrane glycoprotein 1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane protein 1, OTTHUMP00000040663,

Application Dilution:
WB:1:1,000-1:2,000
IHC:1:50-1:200

Specificity: LAMP1 polyclonal antibody detects endogenous levels of LAMP1 protein.

Immunogen:
recombinant protein

MW: 120 kDa

Swiss-Prot: P11279(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.