LAMP2a polyclonal, anti-human, mouse

Background:
Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Alternative Name:
LAMP-2, Lysosome-associated membrane protein 2, LAMP2, CD107 antigen-like family member B, CD107b, LAMP 2, Lamp 2a, LAMP-2, LAMP2, LAMP2, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2,

Application Dilution:
WB:1:500
IHC:1:50-1:200

Specificity: LAMP2a polyclonal antibody detects endogenous levels of LAMP2a protein.

Immunogen:
Synthetic peptide within C-terminal human LAMP2a.

Swiss-Prot: P13473(Human)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.