LARGE Blocking Peptide (Center)
€363.00
In stock
SKU
AC-BP21980c
Background:
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).
Other Names:
Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1,3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1
Target/Specificity:
The synthetic peptide sequence is selected from aa 385-398 of HUMAN LARGE
Gene Name: LARGE1 (HGNC:6511)
Gene ID: 9215
Primary Accession: O95461
Other Accession: Q66PG4;Q66PG1;Q8N3Y3;Q66PG3;Q66PG2;Q9Z1M7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).
Other Names:
Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1,3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1
Target/Specificity:
The synthetic peptide sequence is selected from aa 385-398 of HUMAN LARGE
Gene Name: LARGE1 (HGNC:6511)
Gene ID: 9215
Primary Accession: O95461
Other Accession: Q66PG4;Q66PG1;Q8N3Y3;Q66PG3;Q66PG2;Q9Z1M7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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