LARGE (Center) RB55257 polyclonal, anti-human
€144.00
In stock
SKU
AC-AP21980c
Background:
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).
Other Names: Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1,3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1
Target/Specificity:
This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.
Antigen Type: Synthesized Peptide
Predicted Reactivity: mouse, chicken, zebrafish
Dilution: 1:2000
Calculated MW: 88066
Gene Name: LARGE1 (HGNC:6511)
Gene ID: 9215
Primary Accession: O95461
Primary Accession: Q66PG4, Q66PG1, Q8N3Y3, Q66PG3, Q66PG2, Q9Z1M7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).
Other Names: Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1,3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1
Target/Specificity:
This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.
Antigen Type: Synthesized Peptide
Predicted Reactivity: mouse, chicken, zebrafish
Dilution: 1:2000
Calculated MW: 88066
Gene Name: LARGE1 (HGNC:6511)
Gene ID: 9215
Primary Accession: O95461
Primary Accession: Q66PG4, Q66PG1, Q8N3Y3, Q66PG3, Q66PG2, Q9Z1M7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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