LATH polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60520
Background:
The PLUNC family of proteins are encoded by genes which map to chromosome 20 and are thought to play a potential role in the innate immune response in regions of the mouth, nose and lungs. As a member of the PLUNC family, BASE (breast cancer and salivary gland-expressed protein) is a 179 amino acid secreted protein that is named for its expression pattern. Due to its 63% sequence similarity with the related protein, Latherin, it is suggested that BASE is the major protein in sweat secretions and has important surfactant properties that lower surface tension. The expression pattern of BASE in many breast cancer cell lines suggests that it may be an easily accessible diagnostic breast cancer marker. Due to the fact that the gene encoding BASE is highly estrogen-repressed, expression of the gene is most likely dependent on HNF-3α and estrogen-mediated repression requiring ERα.
Alternative Name:
Putative BPIFA4P protein, BPI fold containing family A, member 4, pseudogene, Breast cancer and salivary gland-expressed protein, Putative latherin, BPIFA4P, BASE, LATH
Application Dilution: WB: 1:500~1:1000
Specificity: LATH polyclonal antibody detects endogenous levels of LATH protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LATH
MW: ~ 19 kDa
Swis Prot.: Q86YQ2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The PLUNC family of proteins are encoded by genes which map to chromosome 20 and are thought to play a potential role in the innate immune response in regions of the mouth, nose and lungs. As a member of the PLUNC family, BASE (breast cancer and salivary gland-expressed protein) is a 179 amino acid secreted protein that is named for its expression pattern. Due to its 63% sequence similarity with the related protein, Latherin, it is suggested that BASE is the major protein in sweat secretions and has important surfactant properties that lower surface tension. The expression pattern of BASE in many breast cancer cell lines suggests that it may be an easily accessible diagnostic breast cancer marker. Due to the fact that the gene encoding BASE is highly estrogen-repressed, expression of the gene is most likely dependent on HNF-3α and estrogen-mediated repression requiring ERα.
Alternative Name:
Putative BPIFA4P protein, BPI fold containing family A, member 4, pseudogene, Breast cancer and salivary gland-expressed protein, Putative latherin, BPIFA4P, BASE, LATH
Application Dilution: WB: 1:500~1:1000
Specificity: LATH polyclonal antibody detects endogenous levels of LATH protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LATH
MW: ~ 19 kDa
Swis Prot.: Q86YQ2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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