Latrophilin-1 Polyclonal Antibody

Background:
adhesion G protein-coupled receptor L1(ADGRL1) Homo sapiens This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],

Alternative Names:
LPHN1, KIAA0821, LEC2, Latrophilin-1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Lectomedin-2

Immunogen: The antiserum was produced against synthesized peptide derived from human LPHN1. AA range:561-610

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

GeneID: LPHN1

Storage: -20°C/1 year

NOTE: For Research Use Only