Latrophilin-2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],function:Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).,tissue specificity:Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.,

Synonyms: LPHN2, KIAA0786, LEC1, LPHH1, Latrophilin-2, Calcium-independent alpha-latrotoxin receptor 2, CIRL-2, Latrophilin homolog 1, Lectomedin-1

Gene Name: LPHN2

Gene ID: 23266

SwissProt ID: O95490

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.