LATS1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7035a
Background:
LATS1 is a serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. LATS1 is a umor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. It negatively regulates G2/M transition by down-regulating CDC2 kinase activity, as well as being involved in the control of p53 expression. LATS1 affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. This protein m ay also play a role in endocrine function. This protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. Sstudies in LATS1 knockout mice show development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Other Names:
Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312|EMBL:AAD168821}
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7035a was selected from the N-term region of human LATS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: LATS1 {ECO:0000312|EMBL:AAD16882.1}
Gene ID: 9113
Primary Accession: O95835
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
LATS1 is a serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. LATS1 is a umor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. It negatively regulates G2/M transition by down-regulating CDC2 kinase activity, as well as being involved in the control of p53 expression. LATS1 affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. This protein m ay also play a role in endocrine function. This protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. Sstudies in LATS1 knockout mice show development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Other Names:
Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312|EMBL:AAD168821}
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7035a was selected from the N-term region of human LATS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: LATS1 {ECO:0000312|EMBL:AAD16882.1}
Gene ID: 9113
Primary Accession: O95835
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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