LATS2 Polyclonal Antibody

Background:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Research Area: Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
FLJ13161, Kinase phosphorylated during mitosis protein, KPM, Large tumor suppressor homolog 2, Large tumor suppressor homolog 2 Drosophila, Large tumor suppressor kinase 2, LATS large tumor suppressor Drosophila homolog 2, LATS large tumor suppressor homolog 2, Lats2, LATS2, Serine/threonine kinase kpm, Serine/threonine protein kinase kpm, Serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, Warts like kinase, Warts-like kinase

Immunogen: Synthetic peptide of human LATS2

Swissprot: Q9NRM7
Gene Accession: NP_055387

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-23067/sc-23065