LC3A polyclonal, anti-human, mouse, rat

Background:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Alternative Name:
MAP1A/MAP1B LC3 A, MAP1LC3A, MAP1A/MAP1B LC3 B, MAP1LC3B, MAP1ALC3, ATG8F, Autophagy related protein LC3 A, Autophagy related protein LC3 B, Autophagy related ubiquitin like modifier LC3 A, Autophagy related ubiquitin like modifier LC3 B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, LC3, MAP1 light chain 3 like protein 1, MAP1 light chain 3 like protein 2, MAP1 light chain 3-like protein 2, MAP1A/1B light chain 3 A, MAP1A/1B light chain 3 B, MAP1A/1BLC3, MAP1A/MAP1B LC3 A, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1BLC3, MAP1LC3A, Map1lc3b, Microtubule associated protein 1 light chain 3 alpha, Microtubule associated protein 1 light chain 3 beta, Microtubule associated proteins 1A/1B light chain 3, Microtubule associated proteins 1A/1B light chain 3A, Microtubule associated proteins 1A/1B light chain 3B, Microtubule-associated protein 1 light chain 3 beta, Microtubule-associated proteins 1A/1B light chain 3B, MLP3B,

Application Dilution:
WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: LC3A polyclonal antibody detects endogenous levels of LC3A protein.

Immunogen:
Peptide

MW: 14/16 kDa

Swiss-Prot: Q9H492(Human) Q91VR7(Mouse) Q6XVN8(Rat)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.