Lck (clone 8E5F9, 4B2C7), anti-human
€539.00
In stock
SKU
252663
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Nervous and Sensory Systems
Description:
Lck (Lymphocyte-specific protein tyrosine kinase) is a 509-amino acid protein (~56kDa), belongs to the Src non-receptor tyrosine kinases family. The Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. Inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Alternate Names: SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, LNK, SH2B3
Application Notes: WB: 1:500-1:2000
Accession No.: Q9UQQ2
Antigen: Purified recombinant fragment of human Lck expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Nervous and Sensory Systems
Description:
Lck (Lymphocyte-specific protein tyrosine kinase) is a 509-amino acid protein (~56kDa), belongs to the Src non-receptor tyrosine kinases family. The Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. Inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Alternate Names: SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, LNK, SH2B3
Application Notes: WB: 1:500-1:2000
Accession No.: Q9UQQ2
Antigen: Purified recombinant fragment of human Lck expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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