LCK polyclonal, anti-human, mouse

Background:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

Synonyms: IMD22, LSK, YT16, p56lck, pp58lck

Cellular Location: Cell membrane Cytoplasm Cytoplasmic side Lipid-anchor

Immunogen:
Recombinant protein of human LCK

Gene Symbol: LCK

Gene ID: 3932

Swiss prot: P06239

Calculated MW: 58kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.