LCP1 (Phospho-Tyr28) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans| two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages| while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts| endothelial cells| epithelial cells| melanocytes| etc.). However| L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Research Area: Cancer, Signal transduction, Epigenetics and nuclear signaling

Synonyms: LCP1 , Tyr28, Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year