LDHA Polyclonal Antibody

Background:
LDHA, also named as LDH-M and NY-REN-59, is an enzyme which catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. LDHA has some isoforms with MW 26-40 kDa.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
Cell proliferation-inducing gene 19 protein, L lactate dehydrogenase A chain, Lactate dehydrogenase A, LDH A, LDH M, LDH muscle subunit, LDH1, LDH5, LDHA, PIG 19, PIG19, Renal carcinoma antigen NY-REN-59

Immunogen: Synthetic peptide of human LDHA

Swissprot: P00338
Gene Accession: NP005557

Calculated MW: 37 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.72 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.