LDLR antibody (clone 50000000), anti-human
€435.00
In stock
SKU
AC-AT2690a
Catalog Number: AC-AT2690a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT2690a">Request Information
Background:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Other Names:
Low-density lipoprotein receptor, LDL receptor, LDLR
Antigen Type:
Recombinant Protein
Gene Name: LDLR
Gene ID: 3949
NCBI Accession: NP_000518.1;NP_001182727.1;NP_001182728.1;NP_001182729.1;NP_001182732.1
Primary Accession: P01130
Other Accession: NM_000527
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Other Names:
Low-density lipoprotein receptor, LDL receptor, LDLR
Antigen Type:
Recombinant Protein
Gene Name: LDLR
Gene ID: 3949
NCBI Accession: NP_000518.1;NP_001182727.1;NP_001182728.1;NP_001182729.1;NP_001182732.1
Primary Accession: P01130
Other Accession: NM_000527
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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