LDLR polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, Transporters

Pathway and Disease: Infectious Diseases, Lipid Metabolism, Membrane Transport, Metabolic Disorders

Description:
The Low-density lipoprotein receptor (LDLR) binds LDL, the major cholesterol-carrying lipoprotein of plasma, on the cell surface in clathrin-coated pits, followed by endocytosis. LDLR defects lead to familial hypercholesterolemia (FH), a common autosomal semi-dominant disease affecting 1 in 500 individuals and characterized by cholesterol deposit in the skin, tendons, and coronary arteries (atherosclerosis). LDLR acts as a receptor for the HIV-1 Tat protein in neurons and mediates its internalization.

Alternate Names: Low-density lipoprotein receptor, LDL-R, Low-density lipoprotein receptor precursor, LDL receptor, LDLR

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P01130

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LDLR.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.