LEP Polyclonal Antibody

Background:
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Stem Cells

Synonyms:
FLJ94114, LEP, LEP, LEPD, Leptin (murine obesity homolog), Leptin (obesity homolog, mouse), Leptin, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, OB, Obese protein, Obese, mouse, homolog of, Obesity, Obesity factor, Obesity homolog mouse, Obesity Murine Homolog Leptin, OBS, OTTHUMP00000212285

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Leptin

Swissprot: P41159,P41160,P50596

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 210 μg/mL
Dilution: IHC 1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.