LEPR Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
CD295, LEP-R, LEPRD, OB-R, OBR, LEPR

Immunogen: A synthetic peptide of human LEPR

Swissprot: P48357
Gene ID: 3953

Calculated MW: 96 kDa/102 kDa/103 kDa/109 kDa/132 kDa
Observed MW: 113 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.