LFG2 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Cell Growth and Death, Signaling Molecules and Interaction

Description:
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. LFG2 (Lifeguard Protein 2) is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, LFG2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. LFG2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. LFG2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. LFG2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

Alternate Names: LFG, LFG2, TMBIM2, Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motic-containing protein 2, FAIM2, NMP35

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: AAF06327

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human LFG2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.