LFNG antibody (clone 2D10-3C11), anti-human
€435.00
In stock
SKU
AC-AT2698a
Catalog Number: AC-AT2698a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
Request Information AC-AT2698a">Request Information
Background:
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG
Antigen Type:
Recombinant Protein
Gene Name: LFNG (HGNC:6560)
Gene ID: 3955
NCBI Accession: NP_001035257.1;NP_001035258.1;NP_001159827.1;NP_002295.1
Primary Accession: Q8NES3
Other Accession: BC014851
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG
Antigen Type:
Recombinant Protein
Gene Name: LFNG (HGNC:6560)
Gene ID: 3955
NCBI Accession: NP_001035257.1;NP_001035258.1;NP_001159827.1;NP_002295.1
Primary Accession: Q8NES3
Other Accession: BC014851
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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