LGMN Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP19953a
Background:
This gene encodes a cysteine protease that has a strictspecificity for hydrolysis of asparaginyl bonds. This enzyme may beinvolved in the processing of bacterial peptides and endogenousproteins for MHC class II presentation in the lysosomal/endosomalsystems. Enzyme activation is triggered by acidic pH and appears tobe autocatalytic. Protein expression occurs after monocytesdifferentiate into dendritic cells. A fully mature, active enzymeis produced following lipopolysaccharide expression in maturedendritic cells. Overexpression of this gene may be associated withthe majority of solid tumor types. This gene has a pseudogene onchromosome 13. Several alternatively spliced transcript variantshave been described, but the biological validity of only two hasbeen determined. These two variants encode the same isoform.
Other Names:
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Target/Specificity:
The synthetic peptide sequence is selected from aa 98-112 of HUMAN LGMN
Gene Name: LGMN {ECO:0000303|PubMed:30425301, ECO:0000312|HGNC:HGNC:9472}
Gene ID: 5641
Primary Accession: Q99538
Other Accession: Q4R4T8; NP_005597.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a cysteine protease that has a strictspecificity for hydrolysis of asparaginyl bonds. This enzyme may beinvolved in the processing of bacterial peptides and endogenousproteins for MHC class II presentation in the lysosomal/endosomalsystems. Enzyme activation is triggered by acidic pH and appears tobe autocatalytic. Protein expression occurs after monocytesdifferentiate into dendritic cells. A fully mature, active enzymeis produced following lipopolysaccharide expression in maturedendritic cells. Overexpression of this gene may be associated withthe majority of solid tumor types. This gene has a pseudogene onchromosome 13. Several alternatively spliced transcript variantshave been described, but the biological validity of only two hasbeen determined. These two variants encode the same isoform.
Other Names:
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Target/Specificity:
The synthetic peptide sequence is selected from aa 98-112 of HUMAN LGMN
Gene Name: LGMN {ECO:0000303|PubMed:30425301, ECO:0000312|HGNC:HGNC:9472}
Gene ID: 5641
Primary Accession: Q99538
Other Accession: Q4R4T8; NP_005597.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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