LGR5/GPR49 polyclonal, anti-human, mouse, rat

Background:
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR5 (leucine-rich repeat-containing G-protein coupled receptor 5), also known as GPR49 or GPR67, is a 907 amino acid multi-pass membrane protein that contains 17 leucine-rich repeats and belongs to the G protein-coupled receptor family. Expressed in placenta, skeletal muscle and spinal cord, LGR5 functions as an orphan receptor that is thought to play an important role in embryonic growth control and cellular differentiation. Overexpression of LGR5 is associated with increased tumor susceptibility and malignant transformation, implicating LGR5 as a potent tumor-inducing protein.

Alternative Name:
LGR5, GPR49, GPR67, FEX, G protein coupled receptor 49, G protein coupled receptor 67, g protein-coupled receptor fex, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR 49, GPR 67, GPR49, GPR67, GRP 49, GRP49, HG 38, HG38, Leucine rich repeat containing G protein coupled receptor 5, Leucine-rich repeat-containing G-protein coupled receptor 5, LGR 5, LGR5, LGR5, MGC117008, Orphan G protein coupled receptor HG38,

Application Dilution:
WB:1:1,000
FC:1:50-1:100

Specificity: LGR5/GPR49 polyclonal antibody detects endogenous levels of LGR5/GPR49 protein.

Immunogen:
recombinant protein

MW: 100 kDa

Swiss-Prot: O75473(Human) Q9Z1P4(Mouse) Unigene: 214063(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.