LGR5 polyclonal, anti-human, mouse, rat antibody
€295.00
In stock
SKU
AC-ABV11666-100
Catalog Number: AC-ABV11666-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, FC
Datasheet
Request Information
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, FC
Datasheet
Request Information
Background:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Other Names:
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67
Primary Accession: O75473
Gene Name: LGR5
Gene ID: 8549
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Other Names:
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67
Primary Accession: O75473
Gene Name: LGR5
Gene ID: 8549
| Is Featured? | No |
|---|
Write Your Own Review