LIG1 Polyclonal Antibody

Background:
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
LIG1

Immunogen: Recombinant fusion protein of human LIG1 (NP_000225.1).

Swissprot: P18858
Gene ID: 3978

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.