LIG4 antibody (clone 1A4), anti-human
€435.00
In stock
SKU
AC-AT2713a
Catalog Number: AC-AT2713a
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: E
Request Information AC-AT2713a">Request Information
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: E
Request Information AC-AT2713a">Request Information
Background:
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
Other Names:
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Antigen Type:
Recombinant Protein
Gene Name: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
NCBI Accession: NP_001091738.1;NP_002303.2;NP_996820.1
Primary Accession: P49917
Other Accession: BC037491
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
Other Names:
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Antigen Type:
Recombinant Protein
Gene Name: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
NCBI Accession: NP_001091738.1;NP_002303.2;NP_996820.1
Primary Accession: P49917
Other Accession: BC037491
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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