LIG4 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP20303a
Catalog Number: AC-AP20303a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB40331
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB40331
Applications: WB
Datasheet
Request Information
Background:
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Other Names:
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Target/Specificity:
This LIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the N-terminal region of human LIG4.
Antigen Region:
239-267
Antigen Type: Synthetic Peptide
Gene Name: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
Primary Accession: P49917
NCBI Accession: NP_001091738.1;NP_002303.2;NP_996820.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Other Names:
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Target/Specificity:
This LIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the N-terminal region of human LIG4.
Antigen Region:
239-267
Antigen Type: Synthetic Peptide
Gene Name: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
Primary Accession: P49917
NCBI Accession: NP_001091738.1;NP_002303.2;NP_996820.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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