LILRB1 antibody (clone 3D3-1D12), anti-human
€435.00
In stock
SKU
AC-AT2715a
Catalog Number: AC-AT2715a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
Request Information AC-AT2715a">Request Information
Background:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Leukocyte immunoglobulin-like receptor subfamily B member 1, LIR-1, Leukocyte immunoglobulin-like receptor 1, CD85 antigen-like family member J, Immunoglobulin-like transcript 2, ILT-2, Monocyte/macrophage immunoglobulin-like receptor 7, MIR-7, CD85j, LILRB1, ILT2, LIR1, MIR7
Antigen Type:
Recombinant Protein
Gene Name: LILRB1 {ECO:0000303|PubMed:20600445, ECO:0000312|HGNC:HGNC:6605}
Gene ID: 10859
NCBI Accession: NP_001075106.1;NP_001075107.1;NP_001075108.1;NP_001265327.1;NP_001265328.1;NP_006660.3
Primary Accession: Q8NHL6
Other Accession: BC015731
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Leukocyte immunoglobulin-like receptor subfamily B member 1, LIR-1, Leukocyte immunoglobulin-like receptor 1, CD85 antigen-like family member J, Immunoglobulin-like transcript 2, ILT-2, Monocyte/macrophage immunoglobulin-like receptor 7, MIR-7, CD85j, LILRB1, ILT2, LIR1, MIR7
Antigen Type:
Recombinant Protein
Gene Name: LILRB1 {ECO:0000303|PubMed:20600445, ECO:0000312|HGNC:HGNC:6605}
Gene ID: 10859
NCBI Accession: NP_001075106.1;NP_001075107.1;NP_001075108.1;NP_001265327.1;NP_001265328.1;NP_006660.3
Primary Accession: Q8NHL6
Other Accession: BC015731
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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